Current Issue : July - September Volume : 2015 Issue Number : 3 Articles : 5 Articles
Background: Melasma and post-inflammatory hyperpigmentation provide a significant source of\npsychosocial morbidity, especially in those with Fitzpatrick skin types III-VI. In Europe, a proprietary\nproduct aimed at treating these conditions, similar to Kligman�s formula but with a longer expiry\ndate, has become available. Objectives: To assess patient satisfaction with a newly available\ncombination de-pigmenting preparation. Methods: We conducted a small study to see if patients\nfelt that this new product affected their quality of life and skin symptoms from hyperpigmentation.\n41 subjects, who had all been prescribed a 15 g tube to use sparingly at night for 90 days within\nthe last 12 months were telephoned to rate the effect the cream had on their quality of life and\nskin symptom improvement. Each patient also had their Dermatology Life Quality Index (DLQI)\nscore assessed. Results: Out of the 29 patients who responded to the study, 22 had melasma and 7\nhad post-inflammatory hyperpigmentation from acne. 21 subjects felt that the cream made either\na marked or moderate improvement on their quality of life and 23 subjects felt that the cream\nmade either a marked or moderate improvement on their skin symptoms. Conclusion: Patients\nreported improvement in both hyperpigmentation and quality of life, suggesting a high level of satisfaction\nwith treatment. The long shelf life of the product may also promote compliance and reduce\nhealth- care costs....
Sensory properties are fundamental in determining the success of a cosmetic\nproduct. In this work, we assessed the influence of different oils and emulsifiers on the\nphysicochemical and sensory properties of anti-ageing cosmetic O/W emulsions containing\nvitamin E acetate as active ingredient. No clear correlation between physicochemical\nproperties and sensory characteristics was evidenced. Sensorial evaluation of these\nformulations pointed out that the emulsifier systems affected the perceived oiliness and\nabsorbency during application of the product, thus influencing its acceptance. These results\nsuggest the need for more detailed studies on the physicochemical factors involved in\ndetermining the consumers� acceptance....
The objective of this work is the preparation of nanocapsules which are intended for the treatment of rheumatoid arthritis (RA).\nWe use Argan oil as vehicle of hydrophobic drugs such as indomethacin. Nanoprecipitation technique was used like a method for\npreparation of nanocapsules, where polycaprolactone, acetone, and Argan oil are used as polymer, solvent, and carrier, respectively.\nPrimarily, investigation of Argan oil amount addition was performed; then systematic study to optimize the formulation was\ndone. Nanocapsules containing indomethacin (loaded nanocapsules) and others without indomethacin (blank nanocapsules) were\ncharacterized by studying particles size, zeta potential, and encapsulation efficiency. It is shown that particle size ranged between\n290 nmand 350 nm.Thezeta potential valueswere negative (from?40 up to ?50mV)while encapsulation efficiency ranged between\n65 and 75%....
The study aimed to evaluate the in vitro properties of a new gel formulation (P-3086) as anti-aging\ntreatment. Two in vitro methods aimed to assess and compare the efficacy of the gel formulation in\nreducing oxidative damages, artificially induced by UVA on skin-derived keratinocytes and in\npromoting the synthesis of collagen, compared with other four formulations. P-3086 reduced\nreactive oxygen species production after UVA stress with the highest effect observed at 0.016\nmg/ml and 0.031 mg/ml concentration. P-3086 also promoted the collagen synthesis faster when\ncompared with other formulations. The new gel product, based on hyaluronic acid, Vitamin E and\nHumulus lupulus, showed a good efficacy as anti-aging effect reducing the oxidative damages derived\nby the action of ROS, moreover stimulating the synthesis of one of the components of the\nconnective tissue, the collagen....
In recent years, the amount of waste deriving from industrial processes has\nincreased substantially. Many industries produce different types of disposable by-products,\nrich in valuable compounds. Their characterization and valorization could not only convert\nthem into high value products with application in diverse biotechnological fields, such as\nPharmaceutics, Food or Cosmetics, but would also reduce the waste environmental impact\nand the related treatment costs. There are many examples of cosmetic active ingredients\nderiving from fish, meat and dairy products, but in the present review we would like to\nfocus on the potentialities and the current use of compounds and extracts deriving from\nagronomical disposable wastes in the cosmetic field. These types of products are effective,\ninexpensive and bio-sustainable, and thus represent a valid alternative to the regular plant\nderived extracts, more commonly adopted in cosmetic formulations. Moreover, if the waste\nproducts come from organic farming, they are certainly an even more valuable source of safe\nextracts for Cosmetics, since they lack any residual pesticide or potentially toxic chemical....
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